This report summarizes information on key chemical exposures for children focusing on those largely related to food. It discusses a number of chemicals or categories of substances including lead, mercury, pesticides, dioxin-like compounds, bisphenol A, phthalates, polybrominated diphenyl ethers (PBDEs) and perfluorinated compounds (PFCs). Toronto Public Health’s (TPH) review of research indicates that the levels of evidence for each of these substances is different. All are of concern to varying degrees; nonetheless all are worth reducing in the diet or from other routes of exposure where feasible. In light of incomplete information on risks to health, this report highlights relevant precautionary advice on ways to reduce or minimize exposure.